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OALib Journal期刊

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The OPTIMIST study: optimisation of cost effectiveness through individualised FSH stimulation dosages for IVF treatment. A randomised controlled trial
Theodora C van Tilborg, Marinus JC Eijkemans, Joop SE Laven, Carolien AM Koks, Jan de Bruin, Gabrielle J Scheffer, Ron JT van Golde, Kathrin Fleischer, Annemieke Hoek, Annemiek W Nap, Walter KH Kuchenbecker, Petra A Manger, Egbert A Brinkhuis, Arne M van Heusden, Alexander V Sluijmer, Arie Verhoeff, Marcel HA van Hooff, Jaap Friederich, Jesper MJ Smeenk, Janet Kwee, Harold R Verhoeve, Cornelis B Lambalk, Frans M Helmerhorst, Fulco van der Veen, Ben Willem J Mol, Helen L Torrance, Frank JM Broekmans
BMC Women's Health , 2012, DOI: 10.1186/1472-6874-12-29
Abstract: Multicentre RCT in subfertile women indicated for a first IVF or intracytoplasmic sperm injection cycle, who are aged？<？44 years, have a regular menstrual cycle and no major abnormalities at transvaginal sonography. Women with polycystic ovary syndrome, endocrine or metabolic abnormalities and women undergoing IVF with oocyte donation, will not be included. Ovarian reserve will be assessed by measuring the antral follicle count. Women with a predicted poor response or hyperresponse will be randomised for a standard versus an individualised FSH regime (150 IU/day, 225-450 IU/day and 100 IU/day, respectively). Participants will undergo a maximum of three stimulation cycles during maximally 18 months. The primary study outcome is the cumulative ongoing pregnancy rate resulting in live birth achieved within 18 months after randomisation. Secondary outcomes are parameters for ovarian response, multiple pregnancies, number of cycles needed per live birth, total IU of FSH per stimulation cycle, and costs. All data will be analysed according to the intention-to-treat principle. Cost-effectiveness analysis will be performed to assess whether the health and associated economic benefits of individualised treatment of subfertile women outweigh the additional costs of an ORT.The results of this study will be integrated into a decision model that compares cost-effectiveness of the three dose-adjustment strategies to a standard dose strategy. The study outcomes will provide scientific foundation for national and international guidelines.NTR2657In vitro fertilisation (IVF) is the treatment of last resort for many subfertile couples and a very costly one, partly due to the use of expensive drugs, i.e. gonadotrophins, needed for controlled ovarian hyperstimulation (COH) [1]. COH is an essential part of IVF which is needed to obtain a reasonable yield of oocytes which can then be fertilised in vitro. In clinical practice physicians often rely on their clinical experience and judgement
Molecular alignment using circularly polarized laser pulses
C T L Smeenk,P B Corkum
Physics , 2013, DOI: 10.1088/0953-4075/46/20/201001
Abstract: We show that circularly polarized femtosecond laser pulses produce field-free alignment in linear and planar molecules. We study the rotational wavepacket evolution of O$_2$ and benzene created by circularly polarized light. For benzene, we align the molecular plane to the plane of polarization. For O$_2$, we demonstrate that circular polarization yields a net alignment along the laser propagation axis at certain phases of the evolution. Circular polarization gives us the ability to control alignment of linear molecules outside the plane of polarization, providing new capabilities for molecular imaging.
Developed Numerical Simulation of Falling and Moving Objects in Viscous Fluids under the Action of a Reynolds Lubrication Theory and Low Reynolds Numbers  [PDF]
Seema Paul, Jesper Oppelstrup
Open Journal of Fluid Dynamics (OJFD) , 2020, DOI: 10.4236/ojfd.2020.101002
Abstract: The development work focuses on the numerical simulations of free body movement in viscous fluid. The aim is to make the simulation of very slow motion of the small body in viscous fluid. We developed bodies’ immersed dynamics simulations in viscous fluid by seeking numerical solutions for appropriate field variables. We developed the methods for vertically and spherically cylindrical objects’ motions, the forces on bodies close to a plane stationary wall are computed from the velocity and pressure fields using the Stokes equation through COMSOL Multiphysics finite element software. The Navier-Stokes equation is reduced to Stokes equation there is independence of time which means object will have an effect only on the motion and the slightly compressible flow assumption is made in order to obtain smooth solution numerically. The forces on an object in slightly compressible Stokes flow have been exerted on the falling objects. The resulting forces have compared with analytical results from the Reynolds Lubrication Theory, and achieved significant results from the development method in Matlab and achieved significant numerical simulations in COMSOL. In addition, an investigation has been made to an object swimming at low Reynolds number. At low Reynolds number moving is possible when object scale is small and flow pattern is slow and sticky. We have developed a system for a thin two-dimensional (2D) worm-like object wiggle that is passing a wave along its centreline and its motion has simulated by the Ordinary Differential Equations (ODE) system and by the Arbitrary Lagrangian-Eulerian (ALE) moving mesh technology. The development method result shows that it is possible for the small object to have a motion from one position to another through small amplitudes and wavelengths in viscous fluid.
Babesia bovis and B. bigemina DNA detected in cattle and ticks from Zimbabwe by polymerase chain reaction
I. Smeenk,P.J. Kelly,K. Wray,G. Musuka
Journal of the South African Veterinary Association , 2012, DOI: 10.4102/jsava.v71i1.671
Abstract: From blood collected from 94 cattle at 12 locations in the eastern and northeastern areas of Zimbabwe, DNA was extracted and analysed by polymerase chain reaction with primers previously reported to be specific for Babesia bigemina and Babesia bovis. Overall, DNA of Babesia bigemina was detected in the blood of 33/94 (35 %) cattle and DNA from B. bovis was detected in 27/58 (47 %) of cattle. The prevalence of DNA of B. bigemina was significantly higher in young animals (<2 years) (23/46) than in animals over 2 years of age (10/48; (chi)2 = 8.77; P < 0.01 %). Although tick sampling was not thorough, Boophilus decoloratus could be collected at 7/9 sites sampled and Boophilus microplus at 4/9 sites. Of the 20 B. decoloratus allowed to oviposit before PCR analysis, 1 (5 %) contained DNA that could be amplified with primers for B. bigemina while 12 (60 %) were positive with primers for B. bovis. Of the B. microplus allowed to oviposit, 11/16 (69 %) were positive for B. bovis DNAby PCR and 2/16 (12 %) were positive for B. bigemina.
Three-dimensional mammography
MJ Yaffe
Breast Cancer Research , 2008, DOI: 10.1186/bcr2009
Abstract:
Contrast enhanced and dual energy mammography
MJ Yaffe
Breast Cancer Research , 2008, DOI: 10.1186/bcr2011
Abstract:
Symptomatic breast clinics: the radiologist's perspective
MJ Michell
Breast Cancer Research , 2006, DOI: 10.1186/bcr1421
Abstract: There has recently been increased pressure on clinics due to improved public awareness of breast disease leading to earlier patient presentation, often with subtle clinical signs. The diagnosis of breast cancer at an earlier stage, contributing to the improved outcome for breast cancer patients, has been accompanied by increased numbers of women presenting to clinics with benign conditions, increasing the workload for radiology services. Further pressure on services has come from increasing expectations from the public who would welcome rapid access to diagnostic clinics regardless of the nature of symptoms and an assurance that all necessary tests would be performed during the same session. Some services have had difficulty with meeting the challenge of both maintaining accuracy and quality at the same time as increasing capacity to meet Health Service waiting time targets.In this presentation, different models of care for breast clinics will be presented with data from the 2006 UK Breast Clinic Survey, and methods for ensuring the most effective and efficient use of radiology resources will be discussed.
The impact of regional integration initiatives and investment in a southern African crossborder region: The Maputo Development Corridor
MJ Roodt
African Sociological Review / Revue Africaine de Sociologie , 2008,
Abstract: No
Social predictors of caesarean section births in Italy
MJ Kambale
African Health Sciences , 2011,
Abstract: Background: Caesarean section birth is a frequent mode of delivery worldwide. Several social factors have been demonstrated to be strong predictors of caesarean births. Objectives: To identify possible social predictors of caesarean section births in Italy. Methods: Data for this study were drawn from the Italian Institute of Statistics (ISTAT) survey conducted during year 2005 which comprised a nationally representative sample of 50,474 households (128,040 subjects). This 2005 ISTAT survey asked several questions to women who delivered (n=5,812) in the past five years prior to the survey about their delivery mode. The main dependent variables were caesarean delivery rates while independent variables included sociodemographics, health and health-related factors. Descriptive statistics, bivariate and multivariate analyses were performed. Results: Our sample comprised 5,812 women. Rate of caesarean deliveries was 36.2 percent. Age (adjOR: 0.961; p=0.000) and residence (Reference: North-West; Centre: adjOR: 0.753, p=0.001; South: adjOR: 0.484, p=0.000; Islands: adjOR: 0.629, p=0.000) were the sole social factors which were significant in predicting caesarean delivery (adjusted model). Conclusions: Rate of caesarean delivery in Italy is rather high. Age and residence are the sole social predictors evidenced from the ISTAT 2005 survey data.
The application of Information and Communication Technology (I.C.T.) in Nigerian academic libraries prospects and problems
MJ Elisha
Information Manager (The) , 2006,
Abstract: Academic libraries play a prominent role in providing information services in various forms to researchers, scientist, policy makers, planners etc. A well organized academic library should have I.C.T. to assist both patrons and information professionals in the libraries. This paper highlights the prospects and problems of I.C.T in Nigeria academic libraries. Recommendation for functional I.C.T. in Nigerian academic library has also been given. The Information Manager Vol. 6 (1&2) 2006: pp. 35-39
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